Statins are one of the most studied classifications of medications in
the pharmaceutical industry as researchers gradually uncover the
fantastic depths of their potential.
As well as their primary purpose of lowering low-density lipoprotein
(LDL) cholesterol aka. ‘bad cholesterol’ and thus decreasing the risk of
cardiovascular disease, statins such as Lipitor (Atorvastatin) and Crestor (Rosuvastatin) have even remarkably been linked with aiding the symptoms of erectile dysfunction, decreasing the risk of liver cancer, and are even being explored in the treatment of asthma.
However, the list of potential benefits
of statins has one new addition, according to the findings of research
published in September’s publication of The FASEB Journal.
A study conducted in Italy shows that statins may slow down the rate
at which telomeres reduce in size – an important factor in our natural
aging process. Therefore, this could pave the way for statins forming
the basis of a revolutionary anti-ageing treatment.
“By telomerase activation, statins may represent a new molecular
switch able to slow down senescent cells in our tissues and be able to
lead healthy lifespan extension,” said Giuseppe Paolisso, M.D., Ph.D., a
researcher involved in the work from the Department of Internal
Medicine, Surgical, Neurological Metabolic Disease and Geriatric
Medicine at Second University of Naples in Naples, Italy.
Paolisso and colleagues divided their study participants into two
groups; one group on statin therapy and a second, control group, who
were not taking statins. Following an analysis of telomerase activity
for both groups, those taking statins were found to have a higher
activity within their white blood cells and thus less telomeres
shortening in comparison to the control group. This shows the importance
of telomerase activation in slowing down the development of many short
telomeres.
You’d be forgiven for not knowing what a ‘telomere’ actually is
though. The ends of our chromosomes are comprised of cells containing a
DNA sequence that helps to prevent the threads of DNA from unravelling; a
fraying effect as a consequence of cell division. These ends are known
as telomeres. Due to the fact they prevent chromosome ends from fraying
and sticking to each other, telomeres are often compared to the plastic
tips on shoelaces.
The importance of telomeres is because each time a cell divides, the
telomeres get shorter. If they shorten too much, the cell becomes unable
to divide and becomes inactive, ‘senescent’ or simply dies. This has
been linked to aging, cancer and an increased risk of death.
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