Viagra patent expires in China – Drug makers scramble to release cheap generics

The quality of these new products may be open to question, but the recent expiry of the Chinese patent for erectile dysfunction (ED) drug Viagra has led to a rush of pharmaceutical companies applying to make their own cheaper generic version of Pfizer’s hugely popular anti-impotence treatment for release in China.

It was recently disclosed that the Viagra patent had expired in China on May 12, almost a year after the UK patent had similarly ended for the ‘little blue pill’, and something which led to Medical Specialists™ Pharmacy offering fantastic bargains on UK-produced inexpensive generic versions of Viagra.

For example, Sildenafil Teva and Sildenafil Actavis were initially introduced into Medical Specialists’™ extensive ED medication range, before even cheaper generic sildenafil was then joined with these last month and resulting in a surge in demand.

It is believed that over a dozen drug makers in China have applied to the China Food and Drug Administration (CFDA) to try and have their own generic versions of Viagra approved for release, with sources claiming many of these actually first began the process around two years ago.

The stigma around erectile dysfunction has been slowly eroded in the 16 years since Pfizer’s Viagra burst onto the scene and more men are now willing to come forward to trusted sources like Medical Specialists™ and seek help. Finally, ED is widely accepted as a genuine health problem that can lead to catastrophic consequences, such as loss of self-esteem, anxiety and even relationship difficulties.
In China alone, the market for ED drugs is now worth an estimated 60 billion Yuan (roughly £5.65 billion) each year.

Also available in China are two of the other most commonly prescribed ED medications – Eli Lilly’s Cialis and Bayer’s Levitra, but Viagra has proved to be the most popular, comprising of over half (58%) of the total sales for ED drugs across 27 major cities in the country last year.

Pfizer China have confirmed they have no immediate plans to release a low-cost version of Viagra regardless of the increase in competition they face.

“For any research-based drug makers, the expiration of a drug patent is a common happening and does not means the end of the world for a product,” Xi Qing, communications director at Pfizer China, said, clearly confident about Viagra keeping a good share of the market in the country.

However, In China about 90% of drugs are generic and it is a market expected to reach 500 billion Yuan by next year. Back in 2011 Pfizer also lost the patent for its money making blockbuster drug Lipitor, which is a commonly prescribed medication for the treatment of high cholesterol.

Lipitor (atorvastatin) brought in staggering revenues for Pfizer that totalled billions of dollars, but that all changed when the patent expired and sales of the branded drug took a serious plunge, and a similar scenario could now happen for Viagra in China.

NHS prescriptions surge to 1 billion in a single year

An incredible milestone has been reached, with a record 1 billion NHS prescriptions dispensed within a single year for the first time ever in England, according to new statistics compiled by the Health and Social Care Information Centre (HSCIC).

The figure was met during 2012 across England and represents a 62% surge from the previous decade, when 383.5 million items were dispensed. The billion prescriptions dispensed is the equivalent of 2.7 million items each a day, or over 1,900 a minute.

Other figures in a report released by the HSCIC show that on average the NHS dispensed 18.7 items per person in 2012, whilst in 2002 it was just 12.4 per person. Moreover, the net cost per item has dropped from £11.10 in 2002 to £8.50 in 2012.

It is believed that an increasingly large and aging population are behind the increase in prescriptions as well as more patents beginning to expire and inexpensive generic alternatives becoming available.
For example, the net cost of the cholesterol-boosting medication atorvastatin (marketed as Lipitor by U.S. Pharmaceutical giant Pfizer) dramatically dropped during 2011 and 2012 from £310.9 million to £166.6 million.

Since then, Pfizer have also lost the UK patent for Viagra, meaning certain other pharmaceutical companies are able to produce an erectile dysfunction medication that contains Viagra’s active ingredient sildenafil citrate, at a significantly lower cost to the patient. Sildenafil Teva and Sildenafil Actavis are two such examples to emerge since the UK Viagra patent ended on June 21.

In what could be a testament to Britain’s burgeoning obesity crisis, for the sixth consecutive year diabetes prescriptions were the biggest cost by treatment area, costing £768 million in 2012 – representing a 2.2% (£16 million) increase from 2011.

Since 1996 the number of people diagnosed with diabetes in the UK has risen from 1.4 million to 2.9 million, of which an estimated 90% are believed to have type 2, which can be caused by either being overweight or obese. Health experts predict that by 2025 5 million people in the UK will have diabetes.

Commenting on the prescription increase, HSCIC chairman Kingsley Manning said: “For the first time, one billion prescription medicines have been dispensed to our communities in just one year. This figure reflects a continuing upward trend in prescription numbers, which is in contrast to a recent fall in total net cost. Total costs have fallen for the second year running and are now at 2009 levels. Our report shows that, while people on average now receive more prescription items, the cost of these per head has dropped in the last two years.”

However, the figures also demonstrate a ‘notable’ rise in the number of antibiotics prescribed – which is causing huge concern. The Government’s chief medical officer has previously spoken of fear that the body’s increasing resistance to antibiotics is one of the biggest threats to modern health.

Professor Dame Sally Davies said many drugs are unnecessarily dished out for mild infections or illnesses and this helping to create a resistance to them, warning that even routine operations such as hip replacements could become fatal if we lose the ability to fight off infection.

Medical Specialists lead the way for ED treatment as Viagra’s UK patent ends

If somebody says the phrase ‘erectile dysfunction’ (ED) or ‘male impotence’, one may instantly think of Pfizer’s wonder drug Viagra. This is mainly because Viagra was the very first oral medication approved for the treatment of erectile dysfunction.

The brand name Viagra will probably always be strongly associated with ED/male impotence and its name alone carries a lot of history and weight behind it. The active ingredient of Viagra ‘sildenafil’ will probably not invoke the same level of familiarity and this chemical name could sound less attractive to men. However, when it boils down to it, that is all Viagra is – sildenafil.

Viagra’s origins are surprisingly traced all the way back to 1989 when a group of pharmaceutical chemists working at Pfizer’s Sandwich, Kent research facility in England, first synthesised sildenafil citrate, a compound that they had high hopes for in the treatment of heart problems such as angina. Two separate Phase 1 trials in addition to one Phase 2 clinical trial over the period of 1991 – 1992 revealed rather unconvincing results for angina treatment, but it became apparent the drug’s strengths lay elsewhere.

By 1994, Pfizer researchers Nicholas Terrett and Peter Ellis noted that men involved in the trial studies of sildenafil citrate as a heart medicine had benefited from increased blood flow into the penis area, aiding those who may previously had difficulty in achieving or sustaining an erection. Over the following three years there were a total of 21 clinical trials conducted, involving nearly 4,500 men. Terrett and Ellis were able to prove sildenafil was both safe and effective as a treatment for erectile dysfunction.

In 1997 the U.S. Food and Drug Administration (FDA) agreed to give Pfizer’s ‘Viagra’ as it was now to be called, a priority review. This is only allocated for drugs which demonstrate large advances in treatment or can be used for a medical need. It was then approved on 27^th March 1998 by the FDA and later given the go-ahead for immediate sale in the European Union in September of the same year.

The popularity of Viagra soon skyrocketed and netted its manufacturer Pfizer billions of dollars each year, even infamously being endorsed in TV adverts by former United States Senator Bob Dole and the Brazilian former world cup winner and football star Pelé. The stigma surrounding men suffering with impotence was finally starting to disappear as men around the world embraced this revolutionary new drug which garnered nicknames such as ‘Vitamin V’, ‘The Little Blue Pill’ and ‘Blue Diamond’.

Men who previously kept their bedroom problems strictly in the bedroom were now willing to discuss this genuine health problem and the fact it is something which can cause deep distress, depression, low self-esteem and can impact relationships. Soon even celebrity figures such as Playboy founder Hugh Hefner were speaking of Viagra’s prowess, with the aging lothario describing Viagra as “God’s little helper”, whilst actor Michael Douglas, married to Catherine Zeta-Jones, raved that Viagra was “a wonderful enhancement . . .that can make us all feel younger.”

This takes us to the present day. Pfizer has seen its market share dramatically decrease in the intervening years due to the entry of Eli Lilly’s Cialis and Bayer’s Levitra and men now have more options available than ever, including the Cialis Daily and Levitra ODT (Orodispersible) variations which have subsequently been introduced. Medical Specialists Pharmacy is one of the leaders in erectile dysfunction treatment and we always have our finger on the pulse regarding the latest treatments for erectile dysfunction and a whole host of other medical conditions.

In fact, if you are not already aware, Pfizer’s UK Viagra patent expired on 21st June 2013 and this now makes it eligible for other pharmaceutical companies to produce an erectile dysfunction medication that contains sildenafil, just like Viagra. This is known as a ‘generic’ alternative. Generic medicines are known for their hugely competitive prices which could prove a massive relief for many of us suffering from the credit crunch-induced hardship.

For some, it is all in the name. Viagra is associated with being the first, and thus best. But let’s not forget what it is actually inside a Viagra tablet – sildenafil.  It could be a blue diamond-shaped tablet or a white oval-shaped tablet, regardless of its outer appearance, the sildenafil contained inside is exactly the same and has the same purpose – to help men suffering from erectile dysfunction to achieve and maintain an erection that is satisfactory for sex.

For more information about the latest erectile dysfunction treatments obtainable from Medical Specialists, visit the male impotence area of the website where we have recently added new treatments such as Sildenafil Teva and Sildenafil Actavis – both at incredibly low prices. Or, if you find tablets difficult to swallow, we also now offer Nipatra (sildenafil) chewable tablets.