Whether you eat the fruit or drink its juice, the large colourful
citrus fruit grapefruit would not probably invoke many, if any, concerns
amongst the majority of people. For starters, its botanical name is
‘fruits of paradise’, which would automatically hint that it is loaded
with a wide range of health boosts. Indeed this is true; grapefruit is
incredibly rich in Vitamin C. So much so that just half of a grapefruit
provides 46.86 mg, (78.1% of the recommended daily intake). The Vitamin C
in grapefruit helps to maintain a healthy immune system, reduce
symptoms of the common cold, and can also reduce the severity of
inflammatory conditions such as asthma, rheumatoid arthritis and
osteoarthritis.
If that wasn’t enough, grapefruit contains chemical compounds called
limonoids, which decrease the risk of death from cancers such as breast,
stomach and pancreatic, and the fruit lowers the chance of death from
heart attack or stroke. This is partly because grapefruit is highly
effective at lowering blood levels of LDL (‘bad’) cholesterol, with red
grapefruit lowering triglycerides as well. It lowers the bad cholesterol
because it contains a soluble fibre known as ‘pectin’ which has been
shown in studies to slow down the progression of atherosclerosis; a
hardening of the arteries that can occur for many reasons including high
cholesterol.
Cholesterol is where a major concern
arises in regards to grapefruit. For those suffering with high
cholesterol, the majority are prescribed statin medication such as
Rosuvastatin (Crestor), Atorvastatin (Lipitor), Lovastatin (Mevacor) and
Simvastatin (Zocor). You may not be aware but statins and grapefruit do
not mix! Although Crestor is widely thought to be safe, grapefruit can
make the active ingredients in Lipitor, Mevacor and Zocor more potent, a
combination that could prove fatal.
This happens as grapefruit contains high levels of the flavanoid
naringin, which interferes with enzymes in the body such as cytochrome
P-450 and P-glycoprotein. Both of these enzymes work at breaking down
drugs like statins and many others, into more usable chemicals, which
are subsequently moved around the body. However, the compounds in
grapefruit cause a drug interaction by inhibiting this metabolism
process of the medications in the digestive system, resulting in a
build-up of the drug’s ingredient in the bloodstream and causing a toxic
poisoning.
The dangerous level of statins in the body may cause liver damage or a
rare disease associated with statins, called ‘rhabdomyolysis’. This
condition is the breakdown of muscle fibre that then triggers the
release of muscle fibre contents called myoglobin into the bloodstream
which is followed by kidney failure (where waste and urine cannot be
removed) and severe muscle damage.
It is not just grapefruit you need to consider though when taking
pharmaceutical drugs. Pomelos and Seville oranges, a type of bitter
orange sometimes used in marmalades and compotes, may also cause
interactions with medicines. Be warned that interactions can occur even
if you eat or drink a small amount of these fruits and researchers are
working to find other types of food that could dangerously react with
particular medications.
If you are prescribed any medicines, not just statins, then you
should immediately check with your own doctor to make sure that it is
safe to consume grapefruit products or indeed any citrus fruits whilst
also taking your medication. Your doctor could advise you to completely
exclude any grapefruit product in your diet, lower your dose of
medication if you are adamant about still having grapefruit in your
diet, or possibly advise a different medication for you.
We have mainly discussed the certain statins that can have an adverse
effect with grapefruit; however there are many other types of drugs
that interact with the fruit. These include:
. Anti-anxiety – Buspirone (Buspar).
. Anti-arrhythmia – Amiodarone (Cordarone), Aronedarone (Multaq).
. Anti-depressant – Sertraline (Zoloft).
. Antihistamine – Fexofenadine (Allegra).
. Cough medicine – Dextromethorphan (Coricidin, Delsym, Dimetapp, NyQuil, Robitussin Vicks and other generic cough medicines).
. Erectile dysfunction – Sildenafil citrate (Viagra).
. High blood pressure – Felodipine (Plendil),
Isradipine (DynaCirc), Nicardipine (Cardene), Nifedipine (Procardia),
Nimodipine (Nimotop), Nisoldipine (Sular).
No comments:
Post a Comment