Tennis Star Andy Murray Joins Fight against Killer Disease

British tennis star Andy Murray is used to facing battles on the tennis court and has begun one this week, as he bids to reclaim a Wimbledon crown he won so famously back during his highly successful period of 2012-13, when he also captured Olympic Gold.

However, one major, global battle that the World number 2 has been proud to join is the fight against the deadly malaria disease.

In 2013 Medical Specialists® Pharmacy reported how Murray had lent his support behind the non-profit charity organisation Malaria No More in a bid to raise both awareness and monetary donations to help the cause, such as funding for vital malaria treatment and mosquito nets.

This year, Murray will be proudly wearing the Malaria No More logo on his sleeve, showing his huge devotion to fighting a tropical disease that is present in around 100 countries worldwide and placing 40% of the world’s population at work.

According to the World Health Organization, about 3.2 billion people – nearly half of the world’s population – are at risk of malaria. Moreover, in 2015, there were roughly 214 million malaria cases and around 438 000 people died from the disease. Increased prevention and control measures have led to a 60% reduction in malaria mortality rates globally since 2000. Sub-Saharan Africa continues to carry a disproportionately high share of the global malaria burden. In 2015, the region was home to 89% of malaria cases and 91% of malaria deaths.

Speaking to the Huffington Post, Murray gave a passionate account of why he is working with the charity and gave a harrowing account of the very real and serious risk to life that malaria poses to millions of people worldwide.

“There’s no tournament on earth like Wimbledon and, after winning here three years ago, I’m looking forward to returning with the home advantage and the incredible support of my fans, and giving it my best shot.

“This year I’m proud to be wearing Malaria No More UK’s logo on my sleeve. I’ve supported the charity’s work to end malaria deaths for seven years now. Two things compelled me to get involved: firstly the devastating impact of malaria on children. This disease claims a young life every two minutes, yet it is preventable and it costs less than a pack of tennis balls to treat and help save a life.

As a new dad this really hits home. You can’t help but imagine how different things would be if you lived in parts of Africa where malaria is the number one killer of young children in your community. It’s unthinkable, yet every day more than 800 children lose their lives because of a mosquito bite. In this day and age, this should not be happening.

“I was also attracted to the malaria campaign because of its single-minded focus, raw ambition and drive to achieve the goal to end malaria deaths in our lifetime. These are qualities that I admire and identify with. With the malaria fight – and from my personal experience – resolute commitment and persistence deliver results.

“For malaria, there’s been record progress to save lives, with child deaths slashed by more than half, saving more than six million lives between 2000 and 2015. That’s more than the entire population of Scotland! This progress is thanks to increased financial commitments and global efforts, supported by UK leadership, which have allowed more prevention (including mosquito nets) and better diagnosis and treatment of the disease.

“I was really interested to hear in April the World Health Organization announce that the European Region hit its 2015 target to wipe out malaria. It’s hard to picture malaria across Europe, but only a hundred years ago you were at risk of catching the disease in nearly every country in the world, so this is huge progress. It gives me hope for the future – we really can be the generation to make malaria no more.

“This September will be a big milestone for the progress to continue as countries will make their pledges to the Global Fund to Fight AIDS, TB and Malaria, the world’s biggest funder of programmes to fight and end these three preventable killers. With renewed commitment and enough funding, eight million more lives could be saved by 2020. I hope all countries, including the UK, will show continued boldness and leadership with strong pledges to save lives.

“In the fight against malaria, when funding has been reduced or stopped many countries have seen the disease return with a vengeance. We cannot afford to stand still or let any ground slip when so many lives and futures are at stake.

“Ending malaria is an incredible and achievable goal that we can all get behind – join me and support Malaria No More UK so that one day in our lifetime no parent anywhere will lose their son or daughter to a preventable disease like malaria. Donate to save lives at malarianomore.org.uk/donate.”

Modified mosquitoes to eradicate malaria?

Researchers claim they have managed to genetically engineer mosquitoes which can resist the malaria infection, doing it in such a way that can nearly ensure the trait will rapidly spread through a population.

Californian researchers have utilised a cutting edge new technique known as gene editing, a technique that involves precise placement of new DNA to enable specific desired effects.
The gene editing technique they used – called CRISPR – allows the new trait to quickly spread and almost guaranteeing the new gene will be transmitted to new generations, limiting the transmission of malaria to humans.

“This opens up the real promise that this technique can be adapted for eliminating malaria,” said Anthony James of the University of California Irvine, who helped lead the study.

“We know the gene works. The mosquitoes we created are not the final brand, but we know this technology allows us to efficiently create large populations.”

The new breed that the researchers looked at were genetically modified Anopheles stephensi mosquitoes – of which normal versions are a common carrier of malaria within India and the Middle East – will not be able to either carry or transmit the deadly disease.

The scientists at the University of California modified the Anopheles stephensi mosquitoes’ DNA with a “resistance” gene, placed into the ‘code’ via a common “cut and paste” gene-altering method known as CRISPR/Cas9.

The technique has previously been utilised to look at the safety of using pig organs safe for human transplants, and produce an HIV-resistant immune system.

Specifically, an analysis was conducted on the mosquitoes’ DNA to try and transmit malaria-fighting antibodies for the particular type of malaria infection that impacts humans that infects humans - Plasmodium falciparum. For the modified mosquitoes, the malarial parasite is either killed off entirely, or stopped from forming into a strain that could be deadly to humans.

The Californian study includes an optimistic future plan to emit the modified mosquitoes into the wild and then the theory is these mosquitoes would give the anti-malarial genes to their offspring, thus generating a resistance to the parasite.

Amazingly, the DNA was successfully passed on to 99.5% of the mosquitoes’ offspring in the lab; genes only have a 50% chance of being passed on usually. In addition, a tracer gene was added to the malaria-resistant one, which would make the modified mosquitoes’ eyes become a fluorescent red in colour.

With further research and development, the team of scientists at the University of California are optimistic they will be able to eventually engineer an anti-malarial mosquito population, helping to eradicate a potentially deadly disease that afflicts millions of people around the globe each year.

Don’t forget, if you are wanting to escape the wet and miserable weather in the UK currently, and are travelling to particularly at-risk countries for malaria, The NHS Malaria Fit For Travel website offers advice about antimalarials such as Malarone and includes a map to show what other serious diseases are rife in certain regions.

Male impotence drug Viagra makes it hard for Malaria to spread

The hugely popular erectile dysfunction medication Viagra (sildenafil citrate) has been taken by men all around the world for over 15 years to help stiffen erections for sex, and it seems this very stiffening prowess has been found to be the key element in aiding a decreased risk in the transmission of the mosquito-borne malaria parasite Plasmodium from humans to mosquitoes. In turn, this would then prevent a further passing of the virus to other people.

The findings have been laid bare in a study conducted by the London School of Hygiene and Tropical Medicine in collaboration with the CNRS, INSERM, Université Paris Descartes at the Institut Cochin and the Institut Pasteur.

How the malaria transmission can be blocked through then use of Viagra was explained by study co-author David Baker, Professor of Malaria Parasite Biology at the London School of Hygiene and Tropical Medicine.

He said: “In this new study we show that Viagra, a drug shown to be safe in humans, can make the sexual forms of the malaria parasite stiff.

“This causes them to be inactivated in the spleen and so prevents transmission of the sexual malaria parasites to mosquitoes. This is an interesting proof of concept which gives us hope that new drugs could be developed that specifically target the malaria parasite phosphodiesterase enzymes and block malaria transmission,” he added.

Plasmodium falciparum is one of the parasites that triggers the infectious, and sometimes deadly disease malaria. This parasite isn’t always easy to treat, with experts believing the single celled organism is evolving to become more resistant to the most commonly prescribed antimalarials. It is this reason why researchers continually look for other ways to fight the disease.

The parasite develops in a person’s red blood cells, which are emitted by bone marrow into the blood stream. Should a mosquito bite somebody that is already infected, it will extract some of the parasites within the blood and there is a risk that the mosquito could then infect another person by biting them.
As the blood circulates, stiff, old or abnormal blood cells are taken in by the spleen, with the healthier normal cells left to travel around. With the Viagra though, the infected red blood cells are taken in by the spleen – meaning they are not available for mosquitoes to get after biting someone. Sildenafil maintains a signalling pathway within the red blood cells, which results in the molecule cAAMP becoming more concentrated and the cells stiffening.

So far, tests have only been conducted using test tubes and there will need to be carried out with animals. If those show signs of success the next trials will need to involve humans before any medication can be approved for the use of malaria prevention.

UK Malaria risk closer could be much higher in future years

Health experts are fearing that increasing temperatures and climate change in the UK could bring an influx of deadly tropical diseases to these shores in the next few decades.

Mosquito-borne diseases such as Malaria, dengue fever, West Nile virus and chikungunya are primarily associated with being prevalent across Africa and Southern America, but could reach Britain in years to come, according to experts writing in The Lancet Infectious Diseases journal by Dr Jolyon Medlock and Professor Steve Leach, of the emergency response department at Public Health England.

Confirmed cases of dengue fever, West Nile virus and chikungunya have already been seen in certain parts of Europe and Greece in particularly has witnessed high numbers of malaria cases as mosquitoes shift into new territories.

Conditions are thought to be warm enough for the Asian tiger mosquito to survive in Britain and this type of blood-sucking insect has already nestled in 25 different European countries, bringing with it dengue fever to Croatia and France, with chikungunya being spread to both Italy and France.

In France alone, there have been 200 cases of chikungunya, and by 2041 in London, conditions could allow for transmission by mosquitoes for one month a year in London by 2041 and for three months in the South-east by 2071 because of predicted temperature rises.

However, in the UK, climate change models are predicting higher temperatures and increased rainfall in the next few decades – offering mosquitoes “ideal conditions” to survive and spread their deadly diseases.

Remarkably, the UK is already thought to be home to up to 34 species of mosquito, with many f of these able to transmit malaria.

There is one climate model that shows that by the year 2030, southern England may generally increase in temperature enough for malaria to be transmitted for up to a third of the year. A different climate model even shows there could be conditions that suffice for malaria to be able to be transmitted for around two months of the year as far up the UK as southern Scotland.

“There is little doubt that climate change will affect vector-borne disease risk,” the authors warn in their paper.

They further state that despite climate change being a clear key issue in the transmission of diseases like dengue fever and malaria, other factors need to be taken into account, such as the availability of water for the mosquitoes to lay their eggs.

If you are travelling abroad and require malaria medication for prevention and treatment, Doxycycline, Malarone, Paludrine, and Jungle Formula Maximum Pump Spray are options worth considering.  In addition, don’t forget to check the NHS Fit For Travel website where you will find the recommended malaria medication for your destination.

Malaria fight backed by England’s football stars

They came face-to-face with the risks themselves during the 2014 World Cup when doctors prescribed them malaria prevention and treatment malarone, but now he England football team have thrown their backing behind the worldwide fight against the deadly disease malaria – a disease that astonishingly claims the life of a child every thirty seconds.

Back in 2007 the England Footballer’s Foundation (EFF) was established on behalf of the England football team, after their generous decision to donate all match fees and time to chosen charities.
Since the foundation began, the EFF has helped to raise more than £3.5million, been responsible for over 150 player appearances, generated three national advertising campaigns and created exclusive EFF events.

And now England stars such as Wayne Rooney and Joe Hart have partnered with Unicef – the world’s leading children’s organisation – in an effort to raise awareness and funds about the danger that malaria poses and the absolute importance of sleeping under mosquito nets for those at risk.

Those most vulnerable are the poorest children in Africa. According to the World Health Organization, in 2012, malaria caused an estimated 627 000 deaths (with an uncertainty range of 473 000 to 789 000), the majority of these being among African children.

To help launch the four-year partnership with Unicef to battle malaria, Rooney and Hart are featured in a poster, together with teammates Gary Cahill and Jack Wilshere, walking hand in hand with schoolchildren.

Globally, malaria is still the third single biggest killer of children, but sleeping under a mosquito net can help to save lives, and this is one important point that the campaign hopes to make at-risk people aware of.

A fundraising evening is taking place later today in London, which is expected to feature a number of England players, such as Danny Welbeck, Alex Oxlade-Chamberlain and Jack Wilshere, who will be in charge of teams facing each other for the coveted EFF Charity Cup.

The Three Lions’ skipper Rooney commented on the campaign, saying: “It’s unbelievable that every 90 minutes – the time it takes to play a football match – 180 children will lose their lives to malaria. As captain of the England football team I am hugely proud that we are able to help Unicef in its goal of protecting every child in danger from this disease.”

Backing up Rooney’s comments, England goalkeeper Hart said: “I am used to defending my goal net against some of the best players in the world, but for some children, being able to sleep under a life-saving mosquito net can mean the last line of defence from this deadly disease. I have always been a huge fan of Unicef’s work so it’s really amazing that through our Foundation we can help make a difference to the lives of some of the world’s most vulnerable children.”

Unicef UK Executive Director David Bull said: “The simplest way to keep children safe from malaria is to ensure that they sleep under a mosquito net, but many are still living without this basic life-saving need. The faces of the England football team are some of the most recognisable in the country so it is great to have them on board to help us raise awareness to tackle malaria and protect all those children in danger.”

World’s first Malaria Vaccine on target for 2015

Health experts are adamant that the the world’s first malaria vaccine will be available on the market by 2015 as another option for malaria prevention, after a hugely encouraging study showed that thousands of deaths could be prevented from the deadly disease.

Publishing their findings in PLOS Medicine, researchers involved in clinical trials of the drug RTS,S, reported that for every 1,000 children who receive the vaccine, around 800 cases of malaria could be prevented.

In follow-up trials 18 months after the initial injections, researchers found RTS,S was remarkably able to offer protection even at that stage.

The vaccine’s manufacturer is pharmaceutical giant GlaxoSmithKline (GSK), the company who produce popular cold sore treatment Zovirax (aciclovir) and weight loss treatment Alli, and they have now requested regulatory approval, meaning this is the first vaccine of its kind to arrive at this milestone.

Several African countries were involved in the trials, mainly as around 90% of deaths from malaria occur in sub-Saharan Africa (SSA), and shockingly 77% of the deaths are children under the age of 5.
An estimated 1,500 infants and children were administered the new RTS,S vaccine and researchers analysed them all again after 18 months, discovering that cases of malaria declined by half in youngsters. For infants (at six to 12 weeks of age when first vaccinated) RTS,S managed to reduce malaria cases by a quarter.

GSK commented: “Over 18 months of follow-up, RTS,S was shown to almost halve the number of malaria cases in young children (aged 5-17 months at first vaccination) and to reduce by around a quarter the malaria cases in infants (aged 6-12 weeks at first vaccination).”

Quite commendably, GSK have pledged to offer their RTS,S vaccine at cost price plus 5%, stating such a move would help to provide the funding for continued research into prevention and treatments for various tropical diseases.

Despite the effectiveness of the malaria vaccine appearing to decline somewhat over time, the report claims it could be highly beneficial to areas where there are high rates of malaria.

For instance, trials demonstrated that in certain Kenyan cities where people are at risk of repeated infection of the deadly disease, around 2,000 cases of clinical malaria were averted for every 1,000 children that were given the vaccine.

GSK say that the vaccine combined with other preventative measures like bed nets and insect repellents (i.e. Jungle Formula), may offer a massive step forward in the battle against malaria. According to the latest estimates into the disease, released in December 2013, there were a staggering 207 million cases of malaria during 2012 and in Africa a child dies every minute because of it.
Scientists are also conducting investigations to determine if a booster may offer even more chances of success.

Professor Sanjeev Krishna of St George’s University of London, did not participate in trials of the vaccine, but did offer a review of the paper for the journal. He said: “This is a milestone. The landscape of malaria vaccine development is littered with carcasses, with vaccines dying left, right and centre. To get to this stage is very encouraging indeed. We eagerly await the next results to see how long-lasting protection is and whether a booster adds further potential. We need to keep a watchful eye for adverse events but everything appears on track for the vaccine to be approved as early as next year.”

Does malaria make you smell more attractive to mosquitoes?

Malaria parasites could change the way people smell and make them more enticing to mosquitoes, according to the findings of new research published in the journal Proceedings of the National Academy of Sciences.

Scientists based at the Swiss Federal Institute of Technology and Pennsylvania State University in the US analysed the odour of mice with and without malaria for a period of 45 days.

To their amazement, the scientists discovered that the scent of the infected mice was significantly different to the mice without the malaria parasite.

The infected mice did not have a completely different odour, however the level of compounds already in the mouse odour was altered.

This was more obvious in the mice that were still infectious but not displaying any symptoms of malaria – an important stage of the parasite’s life cycle.

Professor Consuelo De Moraes of Pennsylvania State University and one of the lead authors involved in the research said: “There appears to be an overall elevation of several compounds that are attractive to mosquitoes.”

The researchers say it is likely that infected people smell more attractive but do not have any highly specific body odours, especially as the malaria pathogen can actually have bad effects for the mosquitoes themselves.

“Since mosquitoes probably don’t benefit from feeding on infected people, it may make sense for the pathogen to exaggerate existing odour cues that the insects are already using for host location,” said study leader Professor Mark Mescher.

Most interesting of all was perhaps that the researchers found that the mice that had been infected seemed to have an alteration in body odour – permanently.

Despite these mice no longer showing any signs of the disease, tests on body odour proved they were carriers of the pathogen.

Those involved in study think it is high probable that there is a similar effect in humans and are now recruiting volunteers in Africa to determine if this is indeed correct.

Professor Mark Mescher told the BBC: “One of the major potential values of this research is if it can help us identify people who do not show symptoms of the disease. Without symptoms people carry the disease without treatment and still transmit it.

“But there is still a long way to go. In mice we have a very controlled environment. In humans there are so many different factors at play – from diverse environments to diverse genes.”

As well as hoping to advance methods of preventing malaria transmission by mosquitoes, researchers also hope to find ways of creating non-invasive diagnostic procedures that would enable the efficient screening of populations for the malaria infection, which would find those who don’t necessarily display malaria symptoms but are still able to spread the disease.

England’s World Cup stars prescribed Malarone to avoid Malaria

With only three days to go until England’s opening Group D game kicks off against Italy, news has emerged that the whole 23-man playing squad are taking the antimalarial Malarone (Atovaquone Proguanil), in addition to 49 additional travelling back-room and administrative staff.

As the following Brazil Malaria Map shows (from the NHS Fit For Travel website) a large portion of the country is alarmingly within the red ‘high risk’ zone for the deadly disease malaria, including the city of Manaus.



Manaus is one of the host cities for the 2014 World Cup and incidentally is where England will begin their quest for World Cup glory on Saturday against the Azzurri, so it is therefore relieving news to know the entire England camp are taking Malarone – Easily one of Medical Specialists™ Pharmacy’s most requested medications from our Holiday and Travel range of treatments.

The Football Association spoke to an expert at the London School of Hygiene and Tropical Medicine and decided the prescribing of Malarone was absolutely vital for the travelling party to Brazil, and all were administered with their first pill during breakfast on Tuesday, 48 hours before leaving for Manaus.

Malarone contains the two active ingredients atovaquone and proguanil hydrochloride, and is used for the prevention and treatment of malaria, a potentially deadly disease that is usually caused by the bite from a female mosquito.

The medication is sought by a high number of people who travel to high-risk countries for malaria, but around one in 10 people who take the drug can experience side effects such as diarrhoea, nausea, vomiting, stomach pain and headaches. One might argue such side effects could be an annoyance if a key England player is affected before the game on Saturday.

However, Medical Specialists™ Pharmacy counter that it is more important that lives are saved, even if there is a risk of one or two players being ruled out of a game, and it is for such reasons that 23 players are taken for games where only 11 can be on the field at once!

It seems manager Roy Hodgson agrees. Although Hodgson didn’t take any Malarone when he visited Manaus in February for the World Cup workshop, he acknowledges the importance of antimalarial treatments such as Malarone.

When asked about any side effects of the drug for his players, he said: “It’s a question for the doctors really: I went to Manaus and I didn’t take any for the two days I spent there. That might just be something to do with the fact that I’m not a football player. As far as I’m concerned, I’ve got to go with medical opinion. If the doctors are telling me that, when we go to Manaus, the players must take malaria tablets, whether it has side effects or not, what do I do? I can’t turn around and say: ‘We will not take malaria tablets’ because the bottom line is it’s better to have stomach cramps or whatever it is for one player in 10 than have someone contract malaria, because that would be unthinkable.”

Malaria moving to higher altitudes due to climate change

Rising temperatures and climate change could put people living in the tropics at risk of contracting the mosquito-borne malaria, according to scientists who have spent two decades monitoring the deadly disease within two densely populated mountainous regions in South America and Africa.

Those residing in higher altitudes have typically not been at risk from the disease, as mosquitoes carrying the malaria parasite find it difficult to survive in the cooler air.

Professor Mercedes Pascual University of Michigan, who led the research, says: “The risk of the disease decreases with altitude and this is why historically people have settled in these higher regions.”

Health experts have spent years arguing if malaria will move because of climate change, and this is one of the only studies of its kind that demonstrates how malaria can migrate higher with a temperature increase. This puts millions of people at risk, who historically have been benefiting from living in malaria-free areas in the high-altitude tropics.

The study involved an analysis of the densely populated areas in the highlands of Colombia and Ethiopia as there were comprehensive records kept for the two of both temperature and malaria cases from the 1990s to 2005.

It was discovered that during warmer years, malaria managed to transmit into the mountains and for the years when the temperatures were cooler, the disease was restricted to lower altitudes.

“We have identified that malaria does indeed move up and down and that the movement is temperature dependent. It’s been difficult to prove and people have been questioning it now for 20 years,” said Menno Bouma of the London School of Hygiene and Tropical Medicine, who was involved in the research.

“The implications are that if this is true, and that a global warming is occurring leading to an increase in temperatures, then malaria will increase at higher altitudes where many people live. The high altitude areas in the tropics are particularly highly populated,” Dr Bouma added.

Dr Bouma says that those in the higher altitudes do not have any protective immunity as they are not exposed to malaria, meaning they could be susceptible to potentially even more serious and fatal cases of the disease.

Around half of Ethiopia’s population live at an altitude between 1,600m (5,250ft) and 2,400m, and the scientists estimate there could be a surge in malaria cases. They predict even just a 1C increase in average local temperatures will mean there will be three million children more children who will contract malaria annually.

“We have estimated that, based on the distribution of malaria with altitude, a 1C rise in temperature could lead to an additional three million cases in under-15-year-olds per year,” says Professor Pascual.

The most recent figures released by the World Health Organization show an estimated 207 million cases of malaria in 2012, resulting in about 627,000 deaths. The majority of these deaths occur among children in Africa. Clearly more work needs to be done into control efforts of the disease, getting malaria treatment and prevention methods to the millions who need them.

In addition, if you are travelling to particularly at-risk countries, The NHS Malaria Fit For Travel website offers advice about antimalarials such as Malarone and includes a map to show what other diseases are common in certain regions.

GSK’s malaria vaccine could be in use by 2015

The world’s very first malaria vaccine could finally be available in 2015 and in widespread use after “significant” results were shown during an ongoing clinical trial. This would offer a significant boost alongside current options for malaria treatment and prevention.

British pharmaceutical giant GlaxoSmithKline (GSK) are behind the development of the new vaccine and say they will be submitting an application for a licence from the European Medicines Agency in the new year.

The vaccine, currently being referred to as RTS, S, has been developed by both GSK together with the non-profit Path Malaria Vaccine Initiative (MVI), supported by funding from the Bill & Melinda Gates Foundation. Trial data has so far been promising in the quest to fight a deadly disease which kills an estimated 660,000 people every year.

RTS, S is one of 20 such vaccines in development, but looks on course to be the first to receive European Medicines Agency approval following hugely encouraging results from Africa’s largest ever clinical trial, involving almost 15,500 babies and children across seven African countries.

Testing showed that after 18 of receiving their vaccination, infants aged between five to 17 months were an incredible 46% less at risk of malaria in comparison to those unvaccinated.  However, infants aged six to 12 weeks when vaccinated were only 27% less at risk.

If the vaccine is fully proved to be safe and effective for use, the World Health Organisation has suggested they are willing to support its widespread use from 2015 onwards. GSK have said they will help to provide fund research into tropical diseases by selling the vaccine at cost price plus 5%, and scientists will next investigate whether a ‘booster dose’ can lengthen protection against malaria in the long-term.

Halidou Tinto, one of the study’s principal investigators, is greatly excited by the vaccines possibilities, saying it had “the potential to have a significant public health impact.”

Tinto commented: “Many millions of malaria cases fill the wards of our hospitals. Progress is being made with bed nets and other measures, but we need more tools to battle this terrible disease.”

GSK chief executive Sir Andrew Witty said: “While we have seen some decline in vaccine efficacy over time, the sheer number of children affected by malaria means that the number of cases of the disease the vaccine can help prevent is impressive. These data support our decision to submit a regulatory application for the vaccine candidate which, if successful, would bring us a step closer to having an additional tool to fight this deadly disease.”

David Lalloo, professor of tropical medicine at Liverpool School of Tropical Medicine, said: “We’ve known about this vaccine for a number of years now and all the studies have shown that it affects around 50 per cent and in younger age groups who don’t have such a good immune response that is down to around 30 per cent. The other concern is that there have been several studies that show it wanes over time…there are still uncertainties about duration and effects. Having said that, given the huge number of malaria deaths and malaria cases, even a relatively small reduction has the potential to make a big difference.”

UK pledge £1 billion in the fight against AIDS, TB and malaria

The UK will give £1 billion to the Geneva-based Global Fund over the next three years in the help to combat AIDS, tuberculosis (TB) and malaria, International Development Secretary Justine Greening has announced at the United Nations in New York. Ms Greening said fighting preventable diseases was “in all of our interests.”

The Global Fund was founded in 2002 and is the world’s largest donor of funds to fight the three deadly and infectious diseases, proving prevention, treatment and care programmes.

The initiative is believed to have helped to save 8.7 million lives and 5.3 million people with HIV are now benefiting from antiretroviral therapy, 11 million new TB cases have been detected and treated and 340 million insecticide treated nets have been given to families to provide protection from malaria.

Britain’s staggering £1 billion pledge will save “a life every three minutes” and now doubles the current amount of money being donated and leaves the UK only second to the United States as the biggest donor of funds.

Throughout the next three years the UK will be involved in the delivery of vital antiretroviral treatment to an additional 750,000 people who have HIV, in addition to an extra 32 million insecticide-treated mosquito nets and over a million people will receive treatment for TB.

The Department for International Development has predicted that the generous funding provided by the UK will save the lives of 590,400 people between 2014 and 2016. This equates to one life saved every three minutes.

“AIDS, TB and malaria are among the world’s biggest killers despite being entirely preventable and treatable,” Ms Greening said at the United Nations General Assembly meeting in New York on Monday, where spoke on the new funding.

She continued: “The Global Fund has already helped save millions of lives but we must keep up the momentum if we are to beat these diseases for good. It is in all our interests to help people live longer, healthier, more productive lives so we all need to play our part in working towards a world free of HIV/Aids, malaria and TB.”

Bono, frontman for rock band U2 co-founder of the One foundation, said: “The UK’s pledge of up to a billion pounds for the fight against Aids, TB and malaria means what once seemed impossible could now be within our grasp. Through this smart investment in one of the most effective disease-fighting funds in history, we could witness the defeat of these global killers in our lifetime. David Cameron and Justine Greening have given us a billion reasons to believe we can do it, but Britain’s pledge will only be delivered if others step up too. Australia, Canada, Germany: your move.”

Prevention of malaria has improved significantly in recent times. The World Health Organisation’s World Malaria Report for 2012 stated that 50 countries were on target for lowering malaria incidence by 75% between 2000 and 2015. Moreover, 30 million insecticide-treated nets were given out during January and July of 2013 through Global Fund-supported programmes.

TB, the world’s second biggest infectious killer after HIV/AIDS, is slowly declining, albeit slowly. Funding from the Global Fund has resulted in detection and treatment of 11 million smear-positive cases of TB, up from 9.7 million at the end of 2012.

It was calculated that as of 1 July the Global Fund had helped to pioneer programmes resulting in 5.3 million people with HIV to receive antiretroviral therapy, up from 4.2 million at the end of 2012.
If you are travelling abroad and require malaria medication for prevention and treatment, Doxycycline, Malarone, Paludrine, and Jungle Formula Maximum Pump Spray are options worth considering.  In addition, don’t forget to check the NHS Fit For Travel website where you will find the recommended malaria medication for your destination.

Huge breakthrough in the quest for a malaria vaccine

A vaccine for one of the world’s biggest killers – malaria – has become a step closer after researchers in the U.S.  made a breakthrough in a small early-stage clinical trial.

The new malaria vaccine is being tentatively named ‘PfSPZ’ and is unique as it contains sporozoites (SPZ) – a life cycle stage of live but weakened malaria Plasmodium falciparum parasites.

Details of the Phase-1 clinical trial were published yesterday in the journal Science. Developers of the vaccine say that the weakened, early stage parasites can actually help a person build up an immunity following an injection of a high enough dosage into the bloodstream.

Lead author Dr Robert Seder, from the Vaccine Research Center at the National Institutes of Health, in Maryland, said: “We were excited and thrilled by the result, but it is important that we repeat it, extend it and do it in larger numbers.”

It has been common knowledge amongst health experts for several decades that exposure to mosquitoes treated with radiation is highly effective as a malaria prevention method.

Unfortunately, evidence shows that roughly 1,000 mosquito bites are required over a time period to gradually develop a sufficient level of immunity.  Therefore, it is simply an unfeasible way to protect people.

Dr Seder added: “Based on the history, we knew dose was important because you needed 1,000 mosquito bites to get protection – this validates that. It allows us in future studies to increase the dose and alter the schedule of the vaccine to further optimise it. The next critical questions will be whether the vaccine is durable over a long period of time and can the vaccine protect against other strains of malaria.”

The new vaccine is being developed by a biotech company called Sanaria, based in Maryland, U.S., who irradiated lab-grown mosquitoes before extracting the malaria-causing parasite Plasmodium falciparum.

Their Phase-1 clinical trial of PfSPZ involved 57 volunteers aged 18 to 45 who had no previous history of the malaria disease. The researchers administered varying strengths of PfSPZ to 40 of the participants and the other 17 received no vaccine whatsoever.

After a week’s analysis, no severe side effects were noted in any of the participants in the study. However, to determine how effective the malaria vaccine actually was, each person – including those who didn’t receive the vaccine – was exposed to bites from five malaria infected mosquitoes.

A week later everybody was analysed for infection and those not given the vaccine received treatment for malaria. It was found that those given high doses were significantly less likely to contract malaria in comparison to the others in the study.

Just three of the 15 participants who received higher doses actually became infected. However, 16 of 17 participants in the lower dosage group became infected and 11 of the 12 participants who were not vaccinated then became infected.

The study, conducted between October 2011 and October 2012, was hugely promising due to the fact none of the participants experienced any side effects from the vaccine. However, the researchers admit it could be years before the vaccine is available in communities where it is needed.

Dr William Schaffner, head of the preventive medicine department at Vanderbilt University’s medical school, said although it was a ‘scientific advance’, it could be as long as a 10 year wait before the malaria vaccine is scientifically proved, given approval, and made available for distribution.

He told CCN: “This is not a vaccine that’s ready for travellers to the developing world anytime soon. However, from the point of view of science dealing with one of the big-three infectious causes of death around the world, it’s a notable advance. And everybody will be holding their breath, watching to see whether this next trial works and how well it works.”

Of course, if you are travelling abroad in the next 10 years and need malaria prevention and treatment, there are other medications available right now. These include Doxycycline, Malarone, Paludrine, and Jungle Formula Maximum Pump Spray.  In addition, don’t forget to check the NHS Fit For Travel website where you will find the recommended malaria medication for your destination.

Andy Murray and Lionel Messi join campaigns to combat malaria

Famous sporting figures from around the world have offered their help in the battle against the potentially-deadly disease malaria.

Tennis star Andy Murray, who yesterday defeated Russian Mikhail Youzhny to reach the quarter finals of Wimbledon, has lent his support to charity Malaria No More UK.

Since their inception in 2009, Malaria No More UK have successfully pushed the coalition government to guarantee malaria is one of the key factors of its international development agenda and have secured a major coup in getting Andy Murray on board for their ‘Be The Net’ campaign – an interactive digital campaign to raise awareness about fighting the disease.

Murray, 26, spoke about malaria to the Huffington Post, saying: "In the past year I’ve won some of the biggest matches of my career but I’m still striving for the world to win the fight against malaria. Every minute a child dies unnecessarily from this disease, yet it is easy to prevent and costs less than a pack of tennis balls to treat. Be The Net is an easy way for us to come together and show our support for this winnable fight, something I am proud to support."

Members of the public are able to insert their face onto a virtual mosquito net via social networking sites Twitter and Facebook, or email and share the activity with their friends or family. Users can also develop their understanding about malaria and the huge challenges there are in combating the disease, in addition to being able email their local MP to show support in the UK’s help in battling malaria and decreasing the risks and deaths caused by it.

Arabella Gilchrist, Director of Communications for Malaria No More UK says: “This campaign is all about getting the public involved and empowered in a democratic movement to fight malaria – one of the best humanitarian investments on the planet. Andy’s the perfect fit for this campaign, he’s tenacious and persistent – Be The Net promotes the message that united we can win.”


However the tennis superstar is not the only sporting figure who is united in fighting malaria. On Thursday 27^th June, Barcelona and Argentina footballer and current FIFA World Player of the Year Lionel Messi arrived for a humanitarian trip to the West African country Senegal.

Messi, 26, was there in conjunction with Qatari football academy ASPIRE Football Dreams to help promote mosquito nets for a new anti-malaria program.

The organisations new initiative – Football Combating Malaria – hopes to distribute an initial 400,000 medicated bed nets across 10 countries in Africa, but aims to have over 1,000,000 to people across the continent each year in the very near future. Nearly 1,000,000 people are thought to have cheated death over the past 12 years by sleeping under nets coated with insecticide.

Despite this, according to the World Health Organization, during 2010 malaria was still responsible for an estimated 660,000 deaths around the world.  The 660,000 deaths emanated from a staggering approximate 219 million cases of the disease, which is preventable and treatable through medicines such as Doxycycline, Malarone and Paludrine.

Around 91% of those fatalities occur in Africa, where most of the deaths are children under the age of 5. Tragically, about 180 children die because of malaria every 90 minutes – the same time duration as a football match.

Speaking to BBC Sport, Messi opened up about the plight of malaria, saying: “I am really delighted to come to Senegal. My commitment to be part of this battle against malaria is relentless. Whenever I have the opportunity to help, I will not hesitate. There is no doubt that I’ll co-operate with organisations involved in this initiative to trim out the pernicious effects of malaria.”

Malaria-infected mosquitoes more enticed by human odour

Malaria-carrying mosquitoes are more drawn to human scent compared with mosquitoes that do not carry the parasite, suggests the findings of a new study.

For the study, led by Dr James Logan of the London School of Hygiene and Tropical Medicine, mosquitoes carrying the malaria parasite Plasmodium falciparum were exposed to nylon socks that had been worn by one of the study authors (Renate Smallegange from Wageningen University in the Netherlands) for about 20 hours previously.

Ms Smallegange state the socks were used as ‘bait’ for the 176 mosquitoes that were analysed in the laboratory. She says: “Volatiles emitted by human feet are known to be highly attractive to Anopheles gambiae females.”

It was estimated that the infected mosquitoes were approximately three times more likely to land and try and bite on the worn socks compared to the mosquitoes without any parasite. For study purposes, the species of mosquito analysed was the Anopheles gambiae – the cause of high transmission rates of malaria in Africa. Both infected and healthier mosquitoes were not particularly keen on unworn socks that were also tested.

Experts are already aware that Anopheles gambiae mosquitoes have certain odour receptors which are effective at picking out specific human scents. The scientists involved in the study are convinced that it is the parasites which are creating a heightened craving for human smells, ergo increasing a risk of UK holiday makers being bitten in the dangerous areas for malaria.

Dr Logan was interviewed by BBC News and explained the findings in the study, commenting: “We think the parasite is giving them a heightened sense of smell. We are hypothesizing there is an alteration somewhere in their olfactory system that allows them to find us quicker,” which would make it more likely that the parasite enters the blood stream, ensuring its survival and the spread of the disease.”

The researchers conclude they are unsure how precisely the parasite alters mosquitoes’ sense of smell, in addition to which component(s) of human odour is the most is deemed most appealing to the mosquitoes as human skin emits over 350 different odour molecules. If this information could be attained from future studies, effective traps could be devised to catch the infected mosquitoes and hopefully lessen the risk of a disease that infects around 200,000 million people around the world each year, killing over 600,000.

If you are about to travel abroad and are unsure of what potential health risks there are or which medications are suitable for your area of travel, Medical Specialists Pharmacy recommend visiting the NHS Fit For Travel website.

Here you can click onto the continent and country you are about to travel to, see a highly detailed list of preventative measures to take before and during travel, what diseases are prominent in that particular country as well as a list of the symptoms of each, and also what medications/immunisations are advisable – i.e. Malarone, Paludrine and Doxycycline are all prescription medications to prevent malaria, with Malarone also able to treat the disease if you contract it. All three are available now from the Medical Specialists Holiday and Travel area of the website, where you can also find treatments for the prevention and control of travel sickness; Kwells, Kwells Kids and Avomine.

Careless Brits dying from Malaria

Whilst we would like to think that we are well educated as regards the risks of contracting malaria when travelling, recent statistics show that many Brits are failing to take the necessary precautions. As a result of this there has been a steady increase since 2007 of Brits contracting malaria whilst abroad.

According to the Health Protection Agency (HPA) the cases of British citizens contracting malaria has increased by over 33% from 2010 to 2011, and more worrying still is the amount of deaths caused by malaria which has nearly doubled.

The reasons for this are many and varied, there has been a large increase in the amount of British people travelling to more exotic locations such as India and West Africa. Added to that is the fact that every year around 2000 Brits come back to the UK suffering from malaria due to not taking any malaria medications.

The reason behind these worrying figures seems to be a lack of education regarding malaria and how dangerous, even how fatal it can be. Some British people do not even realise that they are even entering a malaria zone whilst others do realize but don’t consider malaria to pose a serious threat to their health. Then there are those that think that applying insect spray or sleeping under a mosquito net will be sufficient.

Some people are worried about the possible side effects of anti malaria drugs so avoid taking them, others mistakenly believe that because they have had malaria before or because they have lived in a malaria zone years earlier that they are immune. Another reason is people failing to finish the course of malaria treatment, Malarone for example needs to be taken for seven days after returning.

The NHS advises that if travelling abroad to seek your GP’s advice on which medicine is most suited to both yourself, to where you are going and to make sure your children are given the appropriate paediatric dose. The advice is to also take precautions to avoid getting bit in the first place, this can be done by using an insect repellent (containing 50% deet), using a mosquito net when asleep, keeping bare skin covered up and avoiding being outside between dusk and dawn, the time when mosquitoes are most active.

The Health Protection Agency has stressed the point however that none of these preventative measure can guarantee that you will not get bit, and whilst these measures are certainly worth taking it must be remembered that just one bite is enough to contract malaria.

Therefore this stresses the importance of taking anti malaria drugs, which if taken correctly for the full course can protect you from this potentially fatal disease. Malaria is a completely preventable disease for Britains travelling abroad according to the World Health Organisation, it seems however all that is needed to prevent further Britains contracting malaria is better education.