Male contraceptive pill could be on the horizon with latest breakthrough

A major discovery by Australian researchers could finally bring a male contraceptive pill to fruition and give men more options to equip them and their partners against unwanted pregnancies. Currently condoms such as Durex and Skins for men or the oral contraceptive pill for women, Dianette, are just a few of the choices that are already presently available.

The latest developments follow other research conducted earlier this year by American experts who wanted to push through a male contraceptive pill as they said: “The lack of contraceptive alternatives for men is partially responsible for the high rate of unplanned pregnancies and contributes to the ethical, social and financial costs associated with abortions and deliveries to single mothers.”

Scientists at Monash University in Melbourne say that their findings mean that a pill could be produced that actually kills off the ability of sperm to swim efficiently, living them twiddling their thumbs instead of arriving at their unwanted destination! Furthermore, their findings could also shed some more light on potential factors behind male infertility.

In what seems to be common practice for laboratory tests these days, Lead researcher Professor Moira O’Bryan and her team chose mice to be their subjects for analysis. The team devised a mutation in a gene that is named ‘RABL2’. This gene works at transmitting protein fuel to the engine (known as the axoneme) in a sperm’s tail in mice.

This engineered mutation then led to a reduction in the size of sperm tails by 17% of their ‘normal’ size, and a 50% decrease in the production of sperm.

Most interestingly perhaps was that it was found these particular mice with the mutated gene were left infertile and their sperm were prevented from swimming or moving about anywhere.
Professor O’Bryan says, “They weren’t wriggling or going anywhere, they were just twitching. With this mutation, we get motors that don’t work properly. To be fertile, sperm need motility or swimming ability.”

O’Bryan worked together with fellow scientists from the University of Newcastle, John Curtin School of Medical Research, Garvan Institute of Medical Research and the University of Cambridge for the research. The next step now will be crafting a male contraceptive pill that will work to restrict the RABL2 gene instead of changing or damaging it forever.

Professor O’Bryan continued, “The challenge with developing the male pill isn’t rendering the sperm infertile but turning them back on again.”

The biggest hurdle it seems now for the scientists to overcome is the fact RABL2 is also located in other tissues such as those in the brain, kidneys and liver in lower concentrations. Therefore a male contraceptive pill would have to be constructed in a complex way that has an inhibitor specialised for the testes and will not affect other areas of the body.

Perhaps another hurdle to whether or not male contraceptive pills fully take-off, is if women actually trust the man to take it! This is a subject Medical Specialists Pharmacy looked at briefly in our story mentioned earlier. In addition, it is unknown just when a male pill will even be available. Various studies have been conducted in the last few years but it seems nobody has come forth with a definitive date of release. In the meantime, men could simply opt for the tried and test contraceptive method of condoms, which boast a 98% effectiveness rate. For women, the female birth control pill Dianette has an incredible 99% effective at fulfilling its purpose.

At Medical Specialists Pharmacy, men are already spoilt for choice when it comes to their contraceptive needs. In regards to condoms, Durex and Skins in particularly have an impressive range of weird and wonderful condoms to suit his and her preferences. Some condoms are ultra-thin to the extent you can barely feel it, others are designed to have a ‘tingling’ effect for maximum pleasure, whereas there are also even condoms that come in luscious flavours such as chocolate. If all this isn’t enough, a Durex play vibration ring can be used in conjunction with a condom to add to the pleasure!
Make sure to keep checking the Medical Specialists website for further news, developments and the latest products. We are constantly updating our huge product base and in the next few weeks we will also hope to add Marvelon and Yasmin; two additional female oral contraceptive pills that can also help to fight acne.

Urinary incontinence shown to be prevalent in younger women too

Bladder control problems also known as ‘urinary incontinence’, has long been assumed to primarily affect those women who have recently given birth and those in old age. Besides the fact the problem can also affect males too (with many opting for Tena for men to combat the issue), an Australian study to emerge this week had indicated that urinary incontinence is prevalent amongst those women who have never given birth.

Over 1,000 women between the ages of 16 to 30 were investigated for the study and all subjects had not previously been pregnant. Almost an eighth of the women (equivalent to nearly 13%) complained that they suffered with bladder problems.

Senior researcher Susan R. David, of Monash University in Melbourne, explained the reasoning for undertaking the new study and said, “The traditional belief has been that incontinence really occurs as a consequence of pregnancy and aging. What prompted us to undertake this study was the fact that nobody had actually looked at incontinence in younger women who had never been pregnant.”

Mary K. Townsend, an epidemiologist at Brigham and Women’s Hospital and Harvard Medical School in Boston, was not involved in this particular study but has done previous extensive inquiries into incontinence and its causes. She spoke out regarding the new study and said, “The study contributes significantly to current knowledge about urinary incontinence in young women. Overall, a key message from this study is that urinary incontinence is a significant problem for women of all ages.”
The women involved in the study were from either college campuses or health clinics in Australia. This has resulted in the study authors warning for some degree of caution in interpreting the results and that they may not be completely accurate representative of all women.  Also, only 63% of women who picked up surveys across the campuses or health clinics actually took the time to return them, meaning the results could be an overestimation as those with the problem may be more likely to answer the questions.

The study interestingly discovered that a connection could be present between urinary incontinence and sexually active women who are not using any kind of birth control. This particular group were shown to have the highest risk, with 22% stating they had experience problems in the previous month. This compares to just 10% of the women having urinary problems who had either never have never had sex or were on the pill and sexually active.

Incontinence is not the only urination issue that is common though. On the other end of the scale, other problems can even include the inability to pass urine easily, with some people experiencing a ‘stop and start’ motion in their passing of urine. Or, many people find they have to get up several times in the middle of the night to go to the toilet, sometimes never quite feeling fully emptied.

If you are a male suffering with any of the aforementioned symptoms, there is a chance you could be one of the 2.4 million men in the UK suffering from a condition called benign prostatic hyperplasia (BPH). Also known as an enlarged prostate gland, it can be treated through the use of effective medication such as Flomax Relief, which eases the symptoms associated with lower urinary tract symptoms (LUTS) of a BPH. Flomax works by relaxing muscles in the prostate gland, relaxing the muscles in the urethra (the tube from the bladder to the outside of the body).  This lets urine pass more freely through the urethra, making it easier to urinate. It is available today from the Medical Specialists Pharmacy chemist shop, costing just £8.75 for 14 capsules, or £15.95 for 28.

A contraceptive gel for men could be introduced in the near future

Men are already spoilt for choice when it comes to their contraceptive needs. In regards to condoms, Durex and Skins in particularly have a vast range of different condoms to suit his and her preferences. Some condoms are ultra-thin to the extent you can barely feel it on, some are designed to have a ‘tingling’ effect for maximum pleasure, whereas others actually come in weird and wonderful flavours such as chocolate. If all this isn’t enough, a durex play vibrations ring can be used in conjunction with a condom to add to the pleasure!

However now, scientists in America are claiming that they are in the development stages of formulating a gel for men that can be applied topically as a method of contraception. The gel is said to contain the male hormone testosterone and a synthetic progestin named ‘nesterone’. The two have been tested in the past, but only by injection, a pill form, or via an implant. In addition, these previous tests resulted in such adverse side effects such as effecting cholesterol levels and outbreaks of acne.

Preliminary tests indicated that the gel managed to keep sperm concentration to less than one million sperm per millilitre within 89% of the men involved in the study and who were given the combination of the testosterone and nesterone. The researchers say that this level is low enough to possibly avoid pregnancy with ‘minimal side effects’. This is compared to only 23% of the participants who saw similar effects after only receiving testosterone. It is though that typical sperm concentration is 15 million per every millilitre.

Dr Christina Wang from the Los Angeles Biomedical Research Institute at Harbour-UCLA Medical Center, led the study and commented on the findings at the Endocrine Society’s 94th Annual Meeting in Houston, Texas, “Up until now, the responsibility for contraception has traditionally always been with the female. With these new contraceptive methods for males, the responsibility will be shared.”

However, men should bear in mind that the gel is still in the early stages of production and its success rates of preventing pregnancy will be much lower that condoms, which boast a 98% effectiveness, and also the female birth control pill is an incredible 99% effective. Dr Wang also added that the treatment ‘warrants further study as a male contraceptive.”