Male contraceptive pill could be on the horizon with latest breakthrough

A major discovery by Australian researchers could finally bring a male contraceptive pill to fruition and give men more options to equip them and their partners against unwanted pregnancies. Currently condoms such as Durex and Skins for men or the oral contraceptive pill for women, Dianette, are just a few of the choices that are already presently available.

The latest developments follow other research conducted earlier this year by American experts who wanted to push through a male contraceptive pill as they said: “The lack of contraceptive alternatives for men is partially responsible for the high rate of unplanned pregnancies and contributes to the ethical, social and financial costs associated with abortions and deliveries to single mothers.”

Scientists at Monash University in Melbourne say that their findings mean that a pill could be produced that actually kills off the ability of sperm to swim efficiently, living them twiddling their thumbs instead of arriving at their unwanted destination! Furthermore, their findings could also shed some more light on potential factors behind male infertility.

In what seems to be common practice for laboratory tests these days, Lead researcher Professor Moira O’Bryan and her team chose mice to be their subjects for analysis. The team devised a mutation in a gene that is named ‘RABL2’. This gene works at transmitting protein fuel to the engine (known as the axoneme) in a sperm’s tail in mice.

This engineered mutation then led to a reduction in the size of sperm tails by 17% of their ‘normal’ size, and a 50% decrease in the production of sperm.

Most interestingly perhaps was that it was found these particular mice with the mutated gene were left infertile and their sperm were prevented from swimming or moving about anywhere.
Professor O’Bryan says, “They weren’t wriggling or going anywhere, they were just twitching. With this mutation, we get motors that don’t work properly. To be fertile, sperm need motility or swimming ability.”

O’Bryan worked together with fellow scientists from the University of Newcastle, John Curtin School of Medical Research, Garvan Institute of Medical Research and the University of Cambridge for the research. The next step now will be crafting a male contraceptive pill that will work to restrict the RABL2 gene instead of changing or damaging it forever.

Professor O’Bryan continued, “The challenge with developing the male pill isn’t rendering the sperm infertile but turning them back on again.”

The biggest hurdle it seems now for the scientists to overcome is the fact RABL2 is also located in other tissues such as those in the brain, kidneys and liver in lower concentrations. Therefore a male contraceptive pill would have to be constructed in a complex way that has an inhibitor specialised for the testes and will not affect other areas of the body.

Perhaps another hurdle to whether or not male contraceptive pills fully take-off, is if women actually trust the man to take it! This is a subject Medical Specialists Pharmacy looked at briefly in our story mentioned earlier. In addition, it is unknown just when a male pill will even be available. Various studies have been conducted in the last few years but it seems nobody has come forth with a definitive date of release. In the meantime, men could simply opt for the tried and test contraceptive method of condoms, which boast a 98% effectiveness rate. For women, the female birth control pill Dianette has an incredible 99% effective at fulfilling its purpose.

At Medical Specialists Pharmacy, men are already spoilt for choice when it comes to their contraceptive needs. In regards to condoms, Durex and Skins in particularly have an impressive range of weird and wonderful condoms to suit his and her preferences. Some condoms are ultra-thin to the extent you can barely feel it, others are designed to have a ‘tingling’ effect for maximum pleasure, whereas there are also even condoms that come in luscious flavours such as chocolate. If all this isn’t enough, a Durex play vibration ring can be used in conjunction with a condom to add to the pleasure!
Make sure to keep checking the Medical Specialists website for further news, developments and the latest products. We are constantly updating our huge product base and in the next few weeks we will also hope to add Marvelon and Yasmin; two additional female oral contraceptive pills that can also help to fight acne.

Female oral contraceptive pills could alleviate menstrual cramps

Oral contraceptive pills such as Dianette are taken by women for everyday for 21 days of their menstrual cycle, followed by a 7 day break when no pills are taken at all (also known as ‘cyclic treatment’). During this one week time period, women are still protected against unwanted pregnancies. In the 7 day rest period, hormone levels in the blood begin to decrease and women will experience a withdrawal bleed that is just like a normal period. Regardless of bleeding, the next pack of 21 tablets is begun after the week is up.

However, some experts are now claiming that women could see health benefits from taking the oral contraceptive pills uninterrupted throughout the menstrual cycle instead of adhering to the usual 21 day block. Specifically, the scientists involved in the study into oral contraceptive pills, allege that this continuous usage can provide women with earlier relief from the symptoms of dysmenorrhea.

Dysmenorrhea is one of the most gynaecologic complaints amongst younger women, with an estimated three quarters of them suffering from such problems and the term can basically be defined as ‘painful periods’. For roughly a fifth of women, the pains are so severe and unbearable that it can actually prevent them from going about their day to day activities. Dysmenorrhea happens during menstruation and is thought to occur because of three main reasons; unusual uterine contractions, more pressure on the pelvic region and a heightened sensitivity to pain.

Dr Richard Legro, professor of obstetrics and gynaecology at Penn State College of Medicine, says, “Between 50 and 90 percent of women suffer from this condition, and it can really limit work, school, or athletic performance. Previous studies have estimated that dysmenorrhea accounts for 600 million lost work hours and $2 billion annually.”

The women involved in Dr Legro’s study, were all experiencing inexplicable menstrual pain. This means that health experts could not pinpoint their pains to typical common problems such as ovarian cysts, endometriosis, any past surgical procedures, or other pelvic or bowel diseases.

Dr Legro commented on the aims of his study and said, “Oral contraceptives are often prescribed to treat this condition (dysmenorrhea), since reducing menstruation is a relatively straightforward way to relieve this cramping. However, we wanted to determine whether there was a measurable difference between cyclic and continuous oral contraceptive treatment methods.”

To judge the effects of a cyclic course of treatment vs. a continuous method of taking the contraceptive pills, Dr Legro split the female subjects into two groups and each group spent half a year on that particular therapy. After the evaluation, it was discovered that both groups had actually seen a decline in menstrual pain over this time. Interestingly though, the group assigned the continuous treatment, overall stated they had experienced substantial pain relief earlier on compared to the others.

Despite the promising indications shown in this study, Medical Specialists Pharmacy do not advise women who are taking Dianette to make any alterations to the recommended course of treatment before consulting their own GP first. We believe further analysis is warranted to fully determine the risks and benefits involved with continuously taking oral contraceptive tablets.