Thousands of people who are regular smoker’s claim they cannot quit no matter what they try could blame their genes. Scientists have discovered a brain pathway that, if not functioning correctly, can lead to an uncontrollable desire to smoke.
The fault lies in a receptor protein that is normally activated by the nicotine in cigarettes and dampens the desire for yet more of the drug.
The team found that when rats were genetically changed to block the protein they consumed far more nicotine than control animals. Professor Paul Kenny, of The Scripps Research Institute, Florida
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| Champix Tablets |
In studies, 44% of Champix users were quit during weeks 9 to 12 of treatment (compared to 18% on sugar pill). Champix also helped reduce the urge to smoke. Champix has been proven to be more effective in helping smokers quit than Zyban® (bupropion hydrochloride). The average person in these studies had been a smoker for more than 24 years. The trials involved a mix of men and women who smoked an average of 10 or more cigarettes a day.
Learn about the study.
1,022 patients were enrolled in this study, and results were duplicated in another identically designed clinical trial.Patients received either Champix 1mg twice a day, Zyban 150 mg twice a day, or sugar pills twice a day for 12 weeks. In addition to the pills, patients were given a booklet on quitting smoking and received brief counselling at each visit.
In weeks 9 through 12 in the study, the smoking status of each patient was checked, and the information was compared among the 3 groups. Patients were considered quit if they did not smoke a cigarette (not even a puff) or use other nicotine products for the final 4 weeks of treatment. Champix was proven to be more effective than the sugar pill or Zyban.
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It's extraordinary how much we still have to learn about the brain.
ReplyDeleteIt's especially interesting when chemical imbalances or faulty neural pathways can be shown to b the cause of behaviours that are very often blamed on the individuals involved. Of course nobody has to start smoking, but if there is some reason outside the control of the smoker that stops them quitting, it is hardly fair when the anti-smoking lobby complains about the cost of treating smokers.
Similar issues arise in the mental health field, where there is a lot of misunderstanding and, frankly, still a lot to learn about the causes of depression and other mood disorders.