Results from a study into diabetes conducted by Irish-based doctors were delivered on Monday night at The Endocrine Society’s 94th
Annual Meeting in Houston, Texas. Doctors from Dublin analysed almost
900 males for their ‘Diabetes Prevention Program’. The men who were
involved in the study had an average age of 54 years old and all had
prediabetes, which means they were at a heightened risk of developing
Type 2 diabetes and also at a good risk of developing heart disease.
Prediabetes is also known by other names such as non-diabetic
hyperglycaemia and impaired glucose tolerance.
It is common knowledge that if you are overweight
you are more at risk of developing diabetes. Men who are at risk of the
disease can drastically reduce their chance of getting diabetes through
weight loss and overweight men are also at a higher chance of having
low testosterone levels. With this in mind, study co-author Frances
Hayes and colleagues decided to further investigate the correlation
between weight loss and testosterone levels. They decided to ignore men
who had been prescribed medicine that could potentially conflict with
their testosterone levels, or those who had previously been diagnosed
with hypogonadism. This is a term for when the sex glands lack the
ability to effectively produce hormones.
The men recruited for the study were segregated into three parties.
The first group consisted of 293 men and these were instructed to begin
150 minutes of exercise each week, eating fewer calories and a low-fat
diet. The second group included 305 men and they were given the diabetes
medication metformin and finally the last group of 293 men were given a
placebo to take.
After a year of their respective programs, it was found that the
incidence of low testosterone in both the groups taking metformins and
placebos was mostly unchanged. The numbers slightly decreased from 24.8%
to 23.8% and 25.6% to 24.6% for each group respectively. However, most
change was noted in those who had made alterations to their lifestyle,
with this group seeing a massive reduction in low testosterone; down to
11% from an initial 20% at the beginning of the study.
Dr Hayes gave her view on the results, “Doctors should first
encourage overweight men with low testosterone levels to try to lose
weight through diet and exercise before resorting to testosterone
therapy to raise their hormone levels. Losing weight not only reduces
the risk of prediabetic men progressing to diabetes but also appears to
increase their body’s production of testosterone.”
It appears then that we can conclude weight loss has many benefits to
obese middle-aged men. Obviously it will probably boost their
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