Shares in Pfizer have fallen 2.3% after its latest quarterly profits and earnings target for 2010 both failed to meet market expectations.
The world's largest drugmaker made a net profit of $767m (£481m) in the last three months of 2009, almost triple the $266m it made a year before.
The profits were lifted by Pfizer's $67bn purchase of fellow US pharmaceutical group Wyeth in October.
Revenues at the group were up 34% to $16.5bn.
Excluding one-off items, Pfizer's profits equate to 49 cents per share. Analysts had expected them to total 50 cents per share.
Pfizer said it expects profits of between $2.10 and $2.20 per share for 2010, below market expectations of $2.27 per share.
Its profits for the October to December quarter were much lower in 2008 when it had to pay $2.3bn to settle government allegations that it improperly marketed some of its drugs.
Pfizer is best known for being the producer of the erectile dysfunction drug Viagra.
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Shares in Pfizer have fallen 2.3% after its latest quarterly profits and earnings target for 2010 both failed to meet market expectations.
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